BioMolecules offers services of
custom peptide synthesis, custom conjugation, custom antibody production, and other related
areas. We also provide technical supports in peptide chemistry. If
you need any information not listed in this web page, please feel free to
contact us at 215-891-0415 or through the Contact Us
page, we will be happy to discuss it with you. The following is an outline of our services. Please visit
those pages for more information. Thanks.
The following are only brief descriptions of our
services. For detail, please visit the specific pages below. Thanks.
A full range of services is available: from milligram to gram scale, from
crude to >98% pure. All purified peptides are delivered with HPLC trace and
Mass Spectrum to ensure their quality. Our proprietary synthesizers of multiple
reaction vessels, various synthesis scales, and flexible chemistry protocol
produce high quality peptides with fast turn around time. Peptides are
freeze-dried to get fluffy powder for easier reconstitution. A five-day express
service is also available if you need peptides urgently.
isotope labeled Peptides
Two major isotopes -
N15 and C13 - are implanted in a specific amino acid of
peptides. Each atom contains over 99% enriched
isotope and it can be at more than one position in
Peptides are attached through C-terminal to a core matrix of either 4 or 8
branching Lysine. The loading coupling are carefully monitored. Multiple
antigenic peptides, consisting of highly localized peptide density and high
molecular weight, are suitable for immunizing without conjugation to a carrier
We provide the service of synthesis of combinatorial libraries of amino acids
or other chemical units. The variety of resins, linkers and coupling methods
provide a wide range of services. The libraries can be cleaved from solid support.
It also can be stayed on solid support with a defined linker.
We offer various modified peptides, such as
biotinylated peptides, phosphorylated peptides, dansylated peptides, peptide
alcohols, peptide esters, peptide hydrazides are available. Different synthetic
strategies are designed depending on peptide sequences to fit your
e-mail us your protein
sequences. We will send you a graphic scale of
antigenicity with our comments and make some suggestions of sequences to use as
antigens for antibody production.
Carrier proteins, such as
BSA, KLH or others, are activated by
either homo- or hetero-bifunctional linkers. The activated proteins are purified
right before conjugation to the peptides to ensure high conjugation efficiency. The
resulting mixture is dialysized and lyophilized to get a final product. Our staff
of scientists are happy to discuss available conjugation methods, linkers, and
other factors with you to meet your specific needs.
Princeton BioMolecules provides a range of
full services: including peptide
synthesis, conjugation, and antiserum production using customer¡¯s or our
standard 10 weeks immunization protocol. In general, two NZW female rabbits will
produce 80-100 ml total serum with prebleed, two production bleeds and terminate bleed.
We also provide you information on antigenicity, solubility and related areas for design of peptide sequences.
We'd like to hear from you and provide you with our
extensive services, so your needs can
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