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For the Ionizing Groups of Some Amino Acids at 25oC
| Three
letter code |
Single
letter code |
pK1-COOH |
pK2-NH3+ |
pKR-R group |
pI |
| Ala |
A |
2.34 |
9.86 |
- |
6.10 |
| Arg |
R |
2.01 |
9.04 |
12.48 |
10.76 |
| Asn |
N |
2.02 |
8.80 |
- |
5.41 |
| Asp |
D |
2.10 |
9.82 |
3.86 |
2.98 |
| Cys |
C |
2.04 |
10.25 |
8.33 |
5.02 |
| Glu |
E |
2.10 |
9.47 |
4.07 |
3.08 |
| Gln |
Q |
2.17 |
9.13 |
- |
5.65 |
| Gly |
G |
2.35 |
9.77 |
- |
6.06 |
| His |
H |
1.77 |
9.18 |
6.10 |
7.64 |
| Hyp |
- |
1.92 |
9.73 |
- |
5.82 |
| Ile |
I |
2.31 |
9.75 |
- |
6.03 |
| Leu |
L |
2.32 |
9.74 |
- |
6.03 |
| Lys |
K |
2.18 |
8.95 |
10.53 |
9.47 |
| Met |
M |
2.28 |
9.21 |
- |
5.47 |
| Nle |
- |
- |
|
|
- |
| Nva |
- |
- |
|
|
- |
| Orn |
O |
- |
|
|
- |
| Phe |
F |
2.58 |
9.24 |
- |
5.91 |
| Pro |
P |
2.00 |
10.60 |
- |
6.30 |
| Ser |
S |
2.21 |
9.15 |
- |
5.68 |
| Thr |
T |
2.63 |
10.43 |
- |
- |
| Trp |
W |
2.38 |
9.39 |
- |
5.88 |
| Tyr |
Y |
2.20 |
9.11 |
10.07 |
5.63 |
| Val |
V |
2.28 |
9.71 |
- |
6.00 |
Source: CRC, 67th ed., page C-699.
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