The Structure

    The MAP (Multiple Antigenic Peptides) is a novel tool for generating anti-peptide antibodies.  Peptides are attached through C-terminal to a core matrix of either 4 or 8 branching Lysine, which is called MAP core.  It consists of highly localized peptide density.  The high molecular weight (compared with that of peptide) is  suitable for immunizing without conjugation to a carrier protein.

    Princeton BioMolecules Corporation provides the service of MAP synthesis.  The loading of solid support and the coupling of each amino acid is carefully monitored.  

Characteristics

1. High molar ratio of peptide antigen to core molecule
2. Defined chemical structures
3. Choice of 4-branch, 8 branch, and others
4. Choice of mono-epitope or di-epitope

Advantages

1. Does not require the use of a carrier protein to elicit antibody response
2. Increased coating efficiency on solid surface
3. Enhanced detection sensitivity for solid phase immunoassay
4. Valuable for studies of immunology and vaccine studies

Guidelines

1. Average peptide length: 10-15 residues
2. Favored in N-terminal or internal peptide response 
3. Not favored in C-terminal peptide response 
4. Cysteines can cause low yield 
5. Not amenable for further further purification.

Custom Design

    Our chemists would like to discuss with you about your needs and to develop a MAP system best suited for your needs.

 

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